154 0

Effects of tris(2-butoxyethyl) phosphate exposure on endocrine systems and reproduction of zebrafish (Danio rerio)

Title
Effects of tris(2-butoxyethyl) phosphate exposure on endocrine systems and reproduction of zebrafish (Danio rerio)
Author
문효방
Keywords
TBEOP; Organophosphate flame retardants; Endocrine disruption; HPG axis; Zebraflsh; ORGANOPHOSPHORUS FLAME RETARDANTS; POLYBROMINATED DIPHENYL ETHERS; DISRUPTING COMPOUNDS; MASS-SPECTROMETRY; DRINKING-WATER; AXIS; EXPRESSION; HORMONES; PHARMACEUTICALS; EMBRYOS/LARVAE
Issue Date
2016-06
Publisher
ELSEVIER SCI LTD
Citation
ENVIRONMENTAL POLLUTION, v. 214, Page. 568-574
Abstract
Tris(2-butoxyethyl) phosphate (TBEOP), a widely used organophosphate flame retardant, has frequently been detected both in the environment and the biota. However, limited information is available on the effects of TBEOP on the endocrine system and its underlying mechanisms. We exposed adult zebrafish pairs to TBEOP at concentrations of 0, 2.1,11, and 118 mu g/L for 21 d, and investigated the effects on gene transcription and hormone production related to the hypothalamic-pituitary-gonadal (HPG) axis, and on reproduction. The adverse effects on the F1 generation were further examined. In male fish, plasma concentrations of 17 beta-estradiol were significantly increased along with up-regulation of cyp19a. Exposure to TBEOP at 118 mu g/L to a significant decrease in average egg production. Exposure of the F0 generation to TBEOP delayed hatching and lowered hatching rates in the F1 generation. The results demonstrate that exposure to TBEOP at environmentally relevant concentration levels could affect the sex hormone balance by altering regulatory circuits of the HPG axis, eventually leading to disruption of reproductive performance and the development of offspring. (C) 2016 Elsevier Ltd. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0269749116303177http://hdl.handle.net/20.500.11754/65500
ISSN
0269-7491; 1873-6424
DOI
10.1016/j.envpol.2016.04.049
Appears in Collections:
COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MARINE SCIENCE AND CONVERGENCE ENGINEERING(해양융합공학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE