Repository at Hanyang UniversityCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학)MOLECULAR AND LIFE SCIENCE(분자생명과학과)Articles
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dc.contributor.author안성훈-
dc.date.accessioned2018-04-09T07:55:17Z-
dc.date.available2018-04-09T07:55:17Z-
dc.date.issued2016-06-
dc.identifier.citationMICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, v. 80, No. 3, Page. 545-563en_US
dc.identifier.issn1092-2172-
dc.identifier.issn1098-5557-
dc.identifier.urihttp://mmbr.asm.org/content/80/3/545.short-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/65499-
dc.description.abstractHeterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA (rDNA) heterochromatin, epigenetic states contribute to gene silencing and genome stability, which are required for proper chromosome segregation and a normal life span. Here, we focus on recent advances in the epigenetic regulation of rDNA silencing in Saccharomyces cerevisiae and in mammals, including regulation by several histone modifications and several protein components associated with the inner nuclear membrane within the nucleolus. Finally, we discuss the perturbations of rDNA epigenetic pathways in regulating cellular aging and in causing various types of diseases.en_US
dc.description.sponsorshipThis work was supported by a National Research Foundation of Korea grant funded by the South Korean government (MSIP) (no. 20110030049) and by the research fund of Hanyang University (grant HY-2014-P).en_US
dc.language.isoen_USen_US
dc.publisherAMER SOC MICROBIOLOGYen_US
dc.subjectRNA-POLYMERASE-Ien_US
dc.subjectREMODELING COMPLEX NORCen_US
dc.subjectEXTENDS LIFE-SPANen_US
dc.subjectHISTONE DEACETYLASE COMPLEXESen_US
dc.subjectSISTER-CHROMATID COHESIONen_US
dc.subjectFORK BLOCK PROTEINen_US
dc.subjectSACCHAROMYCES-CEREVISIAEen_US
dc.subjectGENE-TRANSCRIPTIONen_US
dc.subjectNUCLEOLAR DOMINANCEen_US
dc.subjectREPLICATION FORKen_US
dc.titleThe Epigenetic Pathways to Ribosomal DNA Silencingen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume80-
dc.identifier.doi10.1128/MMBR.00005-16-
dc.relation.page545-563-
dc.relation.journalMICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS-
dc.contributor.googleauthorSrivastava, Rakesh-
dc.contributor.googleauthorSrivastava, Rashmi-
dc.contributor.googleauthorAhn, Seong Hoon-
dc.relation.code2016002670-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E]-
dc.sector.departmentDEPARTMENT OF MOLECULAR AND LIFE SCIENCE-
dc.identifier.pidhoon320-
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