The Epigenetic Pathways to Ribosomal DNA Silencing
- Title
- The Epigenetic Pathways to Ribosomal DNA Silencing
- Author
- 안성훈
- Keywords
- RNA-POLYMERASE-I; REMODELING COMPLEX NORC; EXTENDS LIFE-SPAN; HISTONE DEACETYLASE COMPLEXES; SISTER-CHROMATID COHESION; FORK BLOCK PROTEIN; SACCHAROMYCES-CEREVISIAE; GENE-TRANSCRIPTION; NUCLEOLAR DOMINANCE; REPLICATION FORK
- Issue Date
- 2016-06
- Publisher
- AMER SOC MICROBIOLOGY
- Citation
- MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, v. 80, No. 3, Page. 545-563
- Abstract
- Heterochromatin is the transcriptionally repressed portion of eukaryotic chromatin that maintains a condensed appearance throughout the cell cycle. At sites of ribosomal DNA (rDNA) heterochromatin, epigenetic states contribute to gene silencing and genome stability, which are required for proper chromosome segregation and a normal life span. Here, we focus on recent advances in the epigenetic regulation of rDNA silencing in Saccharomyces cerevisiae and in mammals, including regulation by several histone modifications and several protein components associated with the inner nuclear membrane within the nucleolus. Finally, we discuss the perturbations of rDNA epigenetic pathways in regulating cellular aging and in causing various types of diseases.
- URI
- http://mmbr.asm.org/content/80/3/545.shorthttp://hdl.handle.net/20.500.11754/65499
- ISSN
- 1092-2172; 1098-5557
- DOI
- 10.1128/MMBR.00005-16
- Appears in Collections:
- COLLEGE OF SCIENCE AND CONVERGENCE TECHNOLOGY[E](과학기술융합대학) > MOLECULAR AND LIFE SCIENCE(분자생명과학과) > Articles
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