Safety and efficacy of G-CSF mobilization and collection of autologous peripheral blood stem cells in children with cerebral palsy
- Title
- Safety and efficacy of G-CSF mobilization and collection of autologous peripheral blood stem cells in children with cerebral palsy
- Author
- 김승현
- Keywords
- Cerebral palsy; G-CSF; Peripheral blood stem cell; Apheresis
- Issue Date
- 2013-12
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- TRANSFUSION AND APHERESIS SCIENCE, v. 49, no. 3, Page. 516-521
- Abstract
- We hypothesized that mobilized peripheral blood stem cells (PBSCs) could be useful for treating neurological impairments and therefore assessed the safety of administering G-CSF followed by collecting PBSC in children with cerebral palsy (CP). G-CSF (10 mu g/kg/day) was administered subcutaneously for 5 days, and apheresis was performed to collect PBSC via central venous catheter. G-CSF-related events occurred in 3 patients (fever in 2, irritability in 1). No catheter-related complications were reported. None of the patients needed platelet transfusion or calcium replacement during apheresis. Mobilization with G-CSF followed by PBSC collection appears to be safe and feasible in CP children. (C) 2013 Elsevier Ltd. All rights reserved.
- URI
- http://hdl.handle.net/20.500.11754/65323https://www.sciencedirect.com/science/article/pii/S1473050213002796?via%3Dihub
- ISSN
- 1473-0502
- DOI
- 10.1016/j.transci.2013.08.003
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > ETC
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