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Safety and efficacy of G-CSF mobilization and collection of autologous peripheral blood stem cells in children with cerebral palsy

Title
Safety and efficacy of G-CSF mobilization and collection of autologous peripheral blood stem cells in children with cerebral palsy
Author
김승현
Issue Date
2013-12
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
TRANSFUSION AND APHERESIS SCIENCE, v. 49, NO 3, Page. 516-521
Abstract
We hypothesized that mobilized peripheral blood stem cells (PBSCs) could be useful for treating neurological impairments and therefore assessed the safety of administering G-CSF followed by collecting PBSC in children with cerebral palsy (CP). G-CSF (10 mu g/kg/day) was administered subcutaneously for 5 days, and apheresis was performed to collect PBSC via central venous catheter. G-CSF-related events occurred in 3 patients (fever in 2, irritability in 1). No catheter-related complications were reported. None of the patients needed platelet transfusion or calcium replacement during apheresis. Mobilization with G-CSF followed by PBSC collection appears to be safe and feasible in CP children. (C) 2013 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/20.500.11754/65323
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > ETC
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