Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동원 | - |
dc.date.accessioned | 2018-04-04T06:28:37Z | - |
dc.date.available | 2018-04-04T06:28:37Z | - |
dc.date.issued | 2014-12 | - |
dc.identifier.citation | IMMUNOLOGY LETTERS, v. 163, issue 1, Page. 14-21 | - |
dc.identifier.issn | 0165-2478 | - |
dc.identifier.issn | 1879-0542 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/60604 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0165247814002582?via%3Dihub | - |
dc.description.abstract | Triggering receptor expressed on myeloid cells-1 (TREM-1) is induced by 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) in human monocytes/macrophages and epithelial cells. However, little information is available regarding the mechanism of 1,25(OH)2D3-induced TREM-1 expression in human monocytes/macrophages. In this study, 1,25(OH)2D3 was shown to strongly upregulate hypoxia-inducible transcription factor (HIF) in PMA-differentiated U937 cells. However, HIF was not mainly involved in 1,25(OH)2D3-induced TREM-1 expression. Instead, 1,25(OH)2D3-induced expression of TREM-1 was inhibited by rapamycin, a specific inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, indicating the involvement of mTOR. Induction of HIF proteins by 1,25(OH)2D3 was also inhibited by rapamycin. In addition, 1,25(OH)2D3 induced the phosphorylation of p70S6 kinase, a target of mTOR complex 1 (mTORC1). Our results suggest that 1,25(OH)2D3 induces the expression of TREM-1 through the mTOR signaling pathway in human macrophages. | - |
dc.description.sponsorship | This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2013R1A1A2001950). | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | TREM-1 | - |
dc.subject | 1α,25-dihydroxyviamin D3 | - |
dc.subject | mTOR | - |
dc.subject | Monocytes | - |
dc.subject | Macrophages | - |
dc.title | 1,25-Dihydroxyvitamin D3upregulates HIF-1 and TREM-1 via mTORsignaling | - |
dc.type | Article | - |
dc.relation.volume | 163 | - |
dc.identifier.doi | 10.1016/j.imlet.2014.11.004 | - |
dc.relation.page | 14-21 | - |
dc.relation.journal | IMMUNOLOGY LETTERS | - |
dc.contributor.googleauthor | Lee, Bitnara | - |
dc.contributor.googleauthor | Kwon, Eunji | - |
dc.contributor.googleauthor | Kim, Yongjin | - |
dc.contributor.googleauthor | Kim, Jin Hee | - |
dc.contributor.googleauthor | Son, Sang Wook | - |
dc.contributor.googleauthor | Lee, Jin Kyu | - |
dc.contributor.googleauthor | Kim, Dong Won | - |
dc.contributor.googleauthor | Sohn, Jeongwon | - |
dc.contributor.googleauthor | Kim, Tae-Hwan | - |
dc.contributor.googleauthor | Ji, Jong Dae | - |
dc.relation.code | 2014030980 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | dongwkim | - |
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