1,25-Dihydroxyvitamin D3upregulates HIF-1 and TREM-1 via mTORsignaling
- Title
- 1,25-Dihydroxyvitamin D3upregulates HIF-1 and TREM-1 via mTORsignaling
- Author
- 김동원
- Keywords
- TREM-1; 1α,25-dihydroxyviamin D3; mTOR; Monocytes; Macrophages
- Issue Date
- 2014-12
- Publisher
- ELSEVIER SCIENCE BV
- Citation
- IMMUNOLOGY LETTERS, v. 163, issue 1, Page. 14-21
- Abstract
- Triggering receptor expressed on myeloid cells-1 (TREM-1) is induced by 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) in human monocytes/macrophages and epithelial cells. However, little information is available regarding the mechanism of 1,25(OH)2D3-induced TREM-1 expression in human monocytes/macrophages. In this study, 1,25(OH)2D3 was shown to strongly upregulate hypoxia-inducible transcription factor (HIF) in PMA-differentiated U937 cells. However, HIF was not mainly involved in 1,25(OH)2D3-induced TREM-1 expression. Instead, 1,25(OH)2D3-induced expression of TREM-1 was inhibited by rapamycin, a specific inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, indicating the involvement of mTOR. Induction of HIF proteins by 1,25(OH)2D3 was also inhibited by rapamycin. In addition, 1,25(OH)2D3 induced the phosphorylation of p70S6 kinase, a target of mTOR complex 1 (mTORC1). Our results suggest that 1,25(OH)2D3 induces the expression of TREM-1 through the mTOR signaling pathway in human macrophages.
- URI
- http://hdl.handle.net/20.500.11754/60604https://www.sciencedirect.com/science/article/pii/S0165247814002582?via%3Dihub
- ISSN
- 0165-2478; 1879-0542
- DOI
- 10.1016/j.imlet.2014.11.004
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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