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1,25-Dihydroxyvitamin D3upregulates HIF-1 and TREM-1 via mTORsignaling

Title
1,25-Dihydroxyvitamin D3upregulates HIF-1 and TREM-1 via mTORsignaling
Author
이진규
Keywords
TREM-1; 1α,25-dihydroxyviamin D3; mTOR; Monocytes; Macrophages
Issue Date
2015-1
Publisher
ELSEVIER SCIENCE BV
Citation
IMMUNOLOGY LETTERS, v. 163, issue 1, Page. 14-21
Abstract
Triggering receptor expressed on myeloid cells-1 (TREM-1) is induced by 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) in human monocytes/macrophages and epithelial cells. However, little information is available regarding the mechanism of 1,25(OH)2D3-induced TREM-1 expression in human monocytes/macrophages. In this study, 1,25(OH)2D3 was shown to strongly upregulate hypoxia-inducible transcription factor (HIF) in PMA-differentiated U937 cells. However, HIF was not mainly involved in 1,25(OH)2D3-induced TREM-1 expression. Instead, 1,25(OH)2D3-induced expression of TREM-1 was inhibited by rapamycin, a specific inhibitor of the mammalian target of rapamycin (mTOR) signaling pathway, indicating the involvement of mTOR. Induction of HIF proteins by 1,25(OH)2D3 was also inhibited by rapamycin. In addition, 1,25(OH)2D3 induced the phosphorylation of p70S6 kinase, a target of mTOR complex 1 (mTORC1). Our results suggest that 1,25(OH)2D3 induces the expression of TREM-1 through the mTOR signaling pathway in human macrophages.
URI
http://hdl.handle.net/20.500.11754/59797https://www.sciencedirect.com/science/article/pii/S0165247814002582?via%3Dihub
ISSN
0165-2478; 1879-0542
DOI
10.1016/j.imlet.2014.11.004
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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