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전신 자가면역질환에서 여포 보조 T세포의 위상

Title
전신 자가면역질환에서 여포 보조 T세포의 위상
Other Titles
The Niche of Follicular Helper T Cells in Systemic Autoimmune Diseases
Author
윤지희
Keywords
자가면역질환; t임파구; 체액; 배중심; T-Lymphocytes; Helper; Autoimmune Diseases; Immunity, Humoral; Germinal Center
Issue Date
2013-02
Publisher
한양대학교
Citation
Hanyang Medical Reviews, Feb 2013, 33(1), P.1-9
Abstract
Production of thymus-dependent antibodies by autoreactive B cells requires help from T cells. Follicular helper T (Tfh) cells are a unique lineage of CD4+ T subsets present in the follicles of peripheral lymphoid tissues which functions primarily to provide help to cognate B cells. Within germinal centers Tfh cells stimulate germinal center B cells to undergo affinity maturation, Ig class switching, and differentiation to memory B cells and plasma cells. Proposals that activity of Tfh cells is crucial for long-lived humoral autoimmunity are supported by the correlation of numbers and/or functions of Tfh cells with disease activity in many autoimmune disorders. In this review, we discuss recent findings regarding Tfh cell development and function. In addition, we discuss putative roles of Tfh cells in the pathogenesis and highlight the potential of Tfh cells as therapeutic targets in autoimmune diseases.
URI
http://synapse.koreamed.org/DOIx.php?id=10.7599/hmr.2013.33.1.1http://hdl.handle.net/20.500.11754/57780
ISSN
1738-429X; 2234-4446
DOI
10.7599/hmr.2013.33.1.1
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > ETC
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