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Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors

Title
Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors
Author
심지원
Keywords
EMBRYONIC STEM-CELLS; NUCLEAR-PORE; HEMATOPOIETIC PROGENITORS; GENE-REGULATION; BTB/POZ DOMAIN; ACUTE-LEUKEMIA; LYMPH GLAND; NUP98 GENE; PROTEIN; IDENTIFICATION
Issue Date
2014-09
Publisher
ELIFE SCIENCES PUBLICATIONS LTD, SHERATON HOUSE, CASTLE PARK, CAMBRIDGE, CB3 0AX, ENGLAND
Citation
ELIFE, 2014, 3(), P. 1-18
Abstract
Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells. We term the signal from differentiating cells the "equilibrium signal" in order to distinguish it from the "niche signal". Earlier we showed that Equilibrium signaling utilizes Pvr (the Drosophila PDGF/VEGF receptor), STAT92E, and Adenosine deaminase-related growth factor A (ADGF-A) [1]. Little is known about how this signal initiates during hematopoietic development. To identify new genes involved in lymph gland blood progenitor maintenance, particularly those involved in equilibrium signaling, we performed a genetic screen that identified bip1 (bric brac interacting protein 1) and Nucleoporin (Nup98) as additional regulators of the equilibrium signal. We show that the products of these genes along with the Bip1-interacting protein RpS8 (Ribosomal protein S8) are required for the proper expression of Pvr.
URI
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185420/http://hdl.handle.net/20.500.11754/57355
ISSN
2050-084X
DOI
10.7554/eLife.03626
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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