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Intratympanic Steroid Injection for Bell's Palsy: Preliminary Randomized Controlled Study

Title
Intratympanic Steroid Injection for Bell's Palsy: Preliminary Randomized Controlled Study
Author
조석현
Keywords
Bell's palsy; Facial nerve; Idiopathic facial nerve paralysis; Injection; Steroid
Issue Date
2014-10
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
OTOLOGY & NEUROTOLOGY, 35권, 9호, pp.1673-1678
Abstract
Objective: To investigate adjuvant effect and safety of intratympanic steroid for the treatment of Bell's palsy. Study Design: Prospective, investigator blinded, randomized study. Setting: Tertiary referral center. Patients: Patients who received treatment for Bell's palsy from December 2007 to March 2011 were randomly divided into two groups. The control group (n = 17) was treated with systemic steroid plus antiviral agent, and intratympanic steroid injection group (IT group, n = 14) received intratympanic steroid injection combined with medications. Facial functions were evaluated on a regular basis up to 6 months. Intervention: Intratympanic steroid injection. Main Outcome Measures: Facial nerve functions of initial presentation and follow-up were evaluated with House-Brackmann (H-B) system. Primary outcome was complete recovery rate of 6 months. Secondary outcomes included improvement of H-B grade within 3 weeks, time of first improvement in facial function, and cumulative recovery rate. In addition, subgroup analysis of H-B grade over than IV was performed. Results: Complete recovery rate was not different between groups. Time of first improvement was shorter in IT group (p = 0.043). And IT group had a better cumulative recovery rate (p = 0.041) and showed the significant improvement in H-B grade within 3 weeks compared with control group (p = 0.045). In severe facial palsy, complete recovery rate of IT group and control group were 80% and 50% (p = 0.16), and IT groups showed the significant facial improvement within 3 weeks (p = 0.025). And there were no major adverse effects of intratympanic injection. Conclusion: Intratympanic steroid injection might be a safe and useful adjuvant treatment modality for Bell's palsy.
URI
http://ovidsp.tx.ovid.com/sp-3.28.0a/ovidweb.cgi?&S=NDAPFPINHKDDMDJFNCFKLAGCENKDAA00&Link+Set=S.sh.24%7c1%7csl_10http://hdl.handle.net/20.500.11754/56972
ISBN
1537-4505
ISSN
1531-7129
DOI
10.1097/MAO.0000000000000505
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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