74 22

Full metadata record

DC FieldValueLanguage
dc.contributor.author성일훈-
dc.date.accessioned2018-04-03T07:00:06Z-
dc.date.available2018-04-03T07:00:06Z-
dc.date.issued2013-06-
dc.identifier.citationClinics in Orthopedic Surgery, 2013, 5(2), P.145-151en_US
dc.identifier.issn2005-291X-
dc.identifier.urihttps://synapse.koreamed.org/DOIx.php?id=10.4055/cios.2013.5.2.145-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/56946-
dc.description.abstractBackground: This study evaluated the effects of Beraprost sodium (Berasil) on subjective leg symptoms in patients with peripheral arterial disease caused by diabetes mellitus. Methods: Ninety-four diabetic patients with peripheral arterial disease were treated with Beraprost in a fixed-dose, prospective, multicenter, cohort study. Beraprost (40 μg) was administered orally 3 times daily (120 μg/day) for 12 weeks. We developed a new disease-specific symptom questionnaire, which evaluated the effect of peripheral arterial disease on leg discomfort in daily life and assessed therapeutic responses to treatment. Patients were asked for their subjective assessment of symptoms on a written questionnaire before treatment and after 12 weeks of therapy. Results: There was significant improvement in all estimated subjective symptoms (burning, coldness, edema, exertional pain, stabbing, and paresthesias) in the lower extremities at 12 weeks (p < 0.001). There were 18 patients with neuropathy in whom significant improvement was noted for 6 subjective symptoms at 12 weeks (p < 0.05). Adverse events considered to be drug-related were observed in 4 patients (4.3%), all of which were mild and resolved with discontinuation of the medication. Conclusions: Beraprost is effective as a treatment for improving various subjective symptoms in the lower extremities, such as burning, coldness, edema, exertional pain, stabbing, and paresthesias, in diabetic patients with peripheral arterial disease.en_US
dc.language.isoenen_US
dc.publisherThe Korean Orthopaedic Associationen_US
dc.subjectPeripheral arterial diseaseen_US
dc.subjectIntermittent claudicationen_US
dc.subjectDiabetes mellitusen_US
dc.subjectBeraprost sodiumen_US
dc.subjectProstaglandin I2en_US
dc.titleEffects of Beraprost Sodium on Subjective Symptoms in Diabetic Patients with Peripheral Arterial Diseaseen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume5-
dc.identifier.doi10.4055/cios.2013.5.2.145-
dc.relation.page145-151-
dc.relation.journalCLINICS IN ORTHOPEDIC SURGERY-
dc.contributor.googleauthorYoon, H.S.-
dc.contributor.googleauthorChoi, W.J.-
dc.contributor.googleauthorSung, I.H.-
dc.contributor.googleauthorLee, H.S.-
dc.contributor.googleauthorChung, H.J.-
dc.contributor.googleauthorLee, J.W-
dc.relation.code2012232584-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidsungih-


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE