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Incredible RNA: Dual Functions of Coding and Noncoding

Title
Incredible RNA: Dual Functions of Coding and Noncoding
Author
남진우
Keywords
lncRNA; sORF; bifunctional RNA
Issue Date
2016-05
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Citation
MOLECULES AND CELLS, v. 39, NO 5, Page. 367-374
Abstract
Since the RNA world hypothesis was proposed, a large number of regulatory noncoding RNAs (ncRNAs) have been identified in many species, ranging from microorganisms to mammals. During the characterization of these newly discovered RNAs, RNAs having both coding and noncoding functions were discovered, and these were considered bifunctional RNAs. The recent use of computational and high-throughput experimental approaches has revealed increasing evidence of various sources of bifunctional RNAs, such as protein-coding mRNAs with a noncoding isoform and long ncRNAs bearing a small open reading frame. Therefore, the genomic diversity of Janus-faced RNA molecules that have dual characteristics of coding and noncoding indicates that the functional roles of RNAs have to be revisited in cells on a genome-wide scale. Such studies would allow us to further understand the complex gene-regulatory network in cells. In this review, we discuss three major genomic sources of bifunctional RNAs and present a handful of examples of bifunctional RNA along with their functional roles.
URI
http://www.molcells.org/journal/view.html?doi=10.14348/molcells.2016.0039http://hdl.handle.net/20.500.11754/56357
ISSN
1016-8478; 0219-1032
DOI
10.14348/molcells.2016.0039
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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