Dexamethasone loaded r3v6 peptide micelles for gene delivery
- Title
- Dexamethasone loaded r3v6 peptide micelles for gene delivery
- Author
- 이민형
- Keywords
- Amphiphile; Micelle; Plasmid; DNA delivery; Dexamethasone
- Issue Date
- 2011-11
- Publisher
- Medline
- Citation
- Journal of Controlled Release, 2011, 152(1), P.151-152
- Abstract
- R3V6 peptides, which were composed of 3 arginines and 6 valines, formed self-assembled micelles in an aqueous solution. To improve the transfection efficiency of the R3V6 peptide micelles, a hydrophobic drug, dexamethasone was loaded into the core of the R3V6 peptide micelles. In vitro transfection assay showed that the dexamethasone-loaded R3V6 peptide micelles deliver DNA more effectively than the R3V6 micelles. In addition, the dexamethasone-loaded R3V6 micelles reduced the IL-6 levels in the lipopolysaccharide (LPS) activated macrophage cells.
- URI
- http://www.sciencedirect.com/science/article/pii/S0168365911006705http://hdl.handle.net/20.500.11754/54936
- ISSN
- 0168-3659; 1873-4995
- DOI
- 10.1016/j.jconrel.2011.08.056
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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