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Dexamethasone loaded r3v6 peptide micelles for gene delivery

Title
Dexamethasone loaded r3v6 peptide micelles for gene delivery
Author
이민형
Keywords
Amphiphile; Micelle; Plasmid; DNA delivery; Dexamethasone
Issue Date
2011-11
Publisher
Medline
Citation
Journal of Controlled Release, 2011, 152(1), P.151-152
Abstract
R3V6 peptides, which were composed of 3 arginines and 6 valines, formed self-assembled micelles in an aqueous solution. To improve the transfection efficiency of the R3V6 peptide micelles, a hydrophobic drug, dexamethasone was loaded into the core of the R3V6 peptide micelles. In vitro transfection assay showed that the dexamethasone-loaded R3V6 peptide micelles deliver DNA more effectively than the R3V6 micelles. In addition, the dexamethasone-loaded R3V6 micelles reduced the IL-6 levels in the lipopolysaccharide (LPS) activated macrophage cells.
URI
http://www.sciencedirect.com/science/article/pii/S0168365911006705http://hdl.handle.net/20.500.11754/54936
ISSN
0168-3659; 1873-4995
DOI
10.1016/j.jconrel.2011.08.056
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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