Purpose: This study is to find out the meaning and the essence of clinical nurses' interpersonal conflict. Methods:The participants of this research are 7 nurses who work in general hospitals in Seoul. The data were collected from November 1, 2011 until April 30, 2012, and it has been done by in-depth interview. The results were analyzed by Colazzi's phenomenological method. Results: In this study, 5 categories were extracted: 'Conflict due to demanding human relations', 'Conflict due to rigid organizational culture', 'Conflict due to limitation of professional nursing', 'Conflict due to pressure of unconditional sacrifice', 'Conflict due to deficit of therapeutic self environment'. Conclusion: Nurses felt their interpersonal conflicts have deepened. They struggled with conflict and became mature. Finally, nurses overcame the difficulty of interpersonal relations.