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Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization

Title
Carbohydrate-containing Triton X-100 analogues for membrane protein solubilization and stabilization
Author
채필석
Keywords
Carbohydrates; chemistry; Detergents; Membrane Proteins; Micelles; Octoxynol; Protein Stability; Solubility; Surface-Active Agents
Issue Date
2013-04
Publisher
ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Citation
Molecular bioSystems v.9 no.4 ,pp. 626 - 629 , 2013
Abstract
Membrane protein manipulation is a challenging task owing to limited tertiary and quaternary structural stability once the protein has been removed from a lipid bilayer. Such instability can be overcome by embedding membrane proteins in detergent micelles formed from amphiphiles with carefully tuned properties. This study introduces a class of easy-to-synthesize amphiphiles, which are designated CGT (Chae's Glyco-Triton) detergents. Some of the agents are well suited for membrane protein solubilization and stabilization.
URI
http://dx.doi.org/10.1039/c3mb25584khttp://hdl.handle.net/20.500.11754/54566
ISSN
1742-206X
DOI
10.1039/c3mb25584k
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > ETC
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