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dc.contributor.author안주홍-
dc.date.accessioned2018-03-30T06:39:37Z-
dc.date.available2018-03-30T06:39:37Z-
dc.date.issued2014-11-
dc.identifier.citationAnimal Cells and Systems, 2014, 18(6), P.394~398en_US
dc.identifier.issn1976-8354-
dc.identifier.issn2151-2485-
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/19768354.2014.972981-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/54377-
dc.description.abstractInnate immunity in Caenorhabditis elegans involves multiple processes including growth factor pathways, neuroendocrine signaling mediating various kinase activities. In this study, we report that calcineurin, a Ca2+/calmodulin-dependent serine/threonine phosphatase, regulates the nematode's vulnerability to bacterial pathogens. Interestingly, calcineurin seems to differently function in host?pathogen interaction of gram-positive and gram-negative bacteria. In addition, loss of calnexin, a Ca2+-binding chaperone in endoplasmic reticulum, compensates immune response of the nematode to gram-negative bacteria, while that of calreticulin has no effect. The results suggest that C. elegans has evolved different immune response strategy to gram-positive or gram-negative bacteria, utilizing the same immune machinery in different modes.en_US
dc.language.isoenen_US
dc.publisherKorean Society for Integrative Biologyen_US
dc.subjectcalcineurinen_US
dc.subjectcalreticulinen_US
dc.subjectcalnexinen_US
dc.subjectinnate immunityen_US
dc.titleCalcineurin differentially functions in innate immune response of Caenorhabditis elegans fed with grampositive or gram-negative bacteriaen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume18-
dc.identifier.doi10.1080/19768354.2014.972981-
dc.relation.page1-5-
dc.relation.journalAnimal Cells and Systems-
dc.contributor.googleauthorRaymond, Febus-
dc.contributor.googleauthorLee, Sun-Kyung-
dc.contributor.googleauthorAhnn, Joohong-
dc.relation.code2014003323-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidjoohong-
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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