Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 안주홍 | - |
dc.date.accessioned | 2018-03-30T06:39:37Z | - |
dc.date.available | 2018-03-30T06:39:37Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.citation | Animal Cells and Systems, 2014, 18(6), P.394~398 | en_US |
dc.identifier.issn | 1976-8354 | - |
dc.identifier.issn | 2151-2485 | - |
dc.identifier.uri | https://www.tandfonline.com/doi/abs/10.1080/19768354.2014.972981 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/54377 | - |
dc.description.abstract | Innate immunity in Caenorhabditis elegans involves multiple processes including growth factor pathways, neuroendocrine signaling mediating various kinase activities. In this study, we report that calcineurin, a Ca2+/calmodulin-dependent serine/threonine phosphatase, regulates the nematode's vulnerability to bacterial pathogens. Interestingly, calcineurin seems to differently function in host?pathogen interaction of gram-positive and gram-negative bacteria. In addition, loss of calnexin, a Ca2+-binding chaperone in endoplasmic reticulum, compensates immune response of the nematode to gram-negative bacteria, while that of calreticulin has no effect. The results suggest that C. elegans has evolved different immune response strategy to gram-positive or gram-negative bacteria, utilizing the same immune machinery in different modes. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Korean Society for Integrative Biology | en_US |
dc.subject | calcineurin | en_US |
dc.subject | calreticulin | en_US |
dc.subject | calnexin | en_US |
dc.subject | innate immunity | en_US |
dc.title | Calcineurin differentially functions in innate immune response of Caenorhabditis elegans fed with grampositive or gram-negative bacteria | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 18 | - |
dc.identifier.doi | 10.1080/19768354.2014.972981 | - |
dc.relation.page | 1-5 | - |
dc.relation.journal | Animal Cells and Systems | - |
dc.contributor.googleauthor | Raymond, Febus | - |
dc.contributor.googleauthor | Lee, Sun-Kyung | - |
dc.contributor.googleauthor | Ahnn, Joohong | - |
dc.relation.code | 2014003323 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | joohong | - |
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