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Calcineurin differentially functions in innate immune response of Caenorhabditis elegans fed with grampositive or gram-negative bacteria

Title
Calcineurin differentially functions in innate immune response of Caenorhabditis elegans fed with grampositive or gram-negative bacteria
Author
안주홍
Keywords
calcineurin; calreticulin; calnexin; innate immunity
Issue Date
2014-11
Publisher
Korean Society for Integrative Biology
Citation
Animal Cells and Systems, 2014, 18(6), P.394~398
Abstract
Innate immunity in Caenorhabditis elegans involves multiple processes including growth factor pathways, neuroendocrine signaling mediating various kinase activities. In this study, we report that calcineurin, a Ca2+/calmodulin-dependent serine/threonine phosphatase, regulates the nematode's vulnerability to bacterial pathogens. Interestingly, calcineurin seems to differently function in host?pathogen interaction of gram-positive and gram-negative bacteria. In addition, loss of calnexin, a Ca2+-binding chaperone in endoplasmic reticulum, compensates immune response of the nematode to gram-negative bacteria, while that of calreticulin has no effect. The results suggest that C. elegans has evolved different immune response strategy to gram-positive or gram-negative bacteria, utilizing the same immune machinery in different modes.
URI
https://www.tandfonline.com/doi/abs/10.1080/19768354.2014.972981http://hdl.handle.net/20.500.11754/54377
ISSN
1976-8354; 2151-2485
DOI
10.1080/19768354.2014.972981
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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