Doxycycline enhances survival and self-renewal of human pluripotent stem cells
- Title
- Doxycycline enhances survival and self-renewal of human pluripotent stem cells
- Author
- 박장환
- Keywords
- DOPAMINE NEURONS; IN-VITRO; MICROGLIAL ACTIVATION; NEURAL PRECURSORS; HUMAN BLASTOCYSTS; RAT MODEL; DIFFERENTIATION; MINOCYCLINE; DERIVATION; ISCHEMIA
- Issue Date
- 2014-08
- Publisher
- CELL PRESS
- Citation
- Stem cell reports, 2014, 3(2), P.353-364
- Abstract
- We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem cells (NSCs) derived from hESC/iPSCs. These doxycycline effects are not associated with its antibacterial action, but mediated by direct activation of a PI3K-AKT intracellular signal. These findings indicate doxycycline as a useful supplement for stem cell cultures, facilitating their growth and maintenance.
- URI
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175555/http://hdl.handle.net/20.500.11754/54136
- ISSN
- 2213-6711
- DOI
- 10.1016/j.stemcr.2014.06.013
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML