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The Aminopyridinol Derivative BJ-1201 Protects Murine Hippocampal Cells against Glutamate-Induced Neurotoxicity via Heme Oxygenase-1 (Retracted Article. See vol 21, Art no 1463, 2016)

Title
The Aminopyridinol Derivative BJ-1201 Protects Murine Hippocampal Cells against Glutamate-Induced Neurotoxicity via Heme Oxygenase-1 (Retracted Article. See vol 21, Art no 1463, 2016)
Author
남태규
Keywords
aminopyridinol compound BJ-1201; neuroprotection; aminopyridinol HT22; heme oxygenase-1; nuclear transcription factor erythroid-2 related factor 2
Issue Date
2016-05
Publisher
MDPI AG
Citation
MOLECULES, v. 21, No. 5, Article no. 594
Abstract
Glutamate is the major excitatory neurotransmitter in the brain. It can cause neuronal cell damage in the context of oxidative stress. BJ-1201 is a derivative of the compound aminopyridinol, which is known for its antioxidant activity. In this study, we examined the effect of BJ-1201, a 6-(diphenylamino)-2,4,5-trimethylpyridin-3-ol compound, on neuroprotection in HT22 cells. Our data showed that BJ-1201 can protect HT22 cells against glutamate-induced cell cytotoxicity. In addition, BJ-1201 upregulated heme oxygenase-1 (HO-1) to levels comparable to those of the CoPP-treated group. BJ-1201 treatment induced phosphorylation of JNK, but not p38-MAPK or ERK. It also increased the signal in the reporter assay based on beta-galactosidase activity driven by the nuclear transcription factor erythroid-2 related factor 2 (Nrf2) promoter harboring antioxidant response elements (AREs) and induced the translocation of Nrf2. These results demonstrate that BJ-1201 may be a good therapeutic platform against neurodegenerative diseases induced by oxidative stress.
URI
http://www.mdpi.com/1420-3049/21/5/594/htmhttp://hdl.handle.net/20.500.11754/54067
ISSN
1420-3049
DOI
10.3390/molecules21050594
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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