Comparison of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry assay with conventional methods for detection of IMP-6, VIM-2, NDM-1, SIM-1, KPC-1, OXA-23, and OXA-51 carbapenemase-producing Acinetobacter spp., Pseudomonas aeruginosa, and Klebsiella pneumoniae

Title
Comparison of matrix-assisted laser desorption ionization-time-of-flight mass spectrometry assay with conventional methods for detection of IMP-6, VIM-2, NDM-1, SIM-1, KPC-1, OXA-23, and OXA-51 carbapenemase-producing Acinetobacter spp., Pseudomonas aeruginosa, and Klebsiella pneumoniae
Author
이양순
Keywords
MALDI-TOF MS; SIM-1; OXA; Carbapenemase; Acinetobacter spp
Issue Date
2013-09
Publisher
Elsevier Science INC
Citation
Diagnostic Microbiology and Infectious Disease, 2013, 77, P.227-230
Abstract
Matrix-assisted laser desorption ionization-time-of-flight mass spectrometry assay was able to detect carbapenemase producers, including SIM-1 or OXA-51, within 4 hours using 20 mu L of 0.5 g/L ertapenem solution as a substrate. This assay is more rapid and accurate than the modified Hodge test and 3-dimensional extract bioassay. Hence, it can be used an alternative test to identify carbapenemase-mediated carbapenem resistance in Gram-negative bacteria. (C) 2013 Elsevier Inc. All rights reserved.
URI
https://www.dmidjournal.com/article/S0732-8893(13)00398-2/fulltext
ISSN
0732-8893
DOI
10.1016/j.diagmicrobio.2013.07.005
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > ETC
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