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Influence of initial angiotensin receptor blockers on treatment persistence in uncomplicated hypertension: A nation-wide population-based study

Title
Influence of initial angiotensin receptor blockers on treatment persistence in uncomplicated hypertension: A nation-wide population-based study
Author
이주연
Keywords
losartan; hypertension; persistence; angiotensin-receptor blocker; Adherence
Issue Date
2016-05
Publisher
TAYLOR & FRANCIS INC
Citation
CLINICAL AND EXPERIMENTAL HYPERTENSION, v. 38, No. 3, Page. 325-330
Abstract
We identified 55 504 uncomplicated, treatment-naive hypertensive patients who started angiotensin II receptor blockers (ARBs) in 2012 from national claims data. The proportion of patients remaining on any hypertension treatment at 12 months and the adherence rate were similar between the losartan cohort (66.82% and 68.25%) and the nonlosartan ARB cohort (67.48% and 69.01%). After adjusting for confounding factors, there was no difference in persistence (aHR 0.98, 95% confidence interval (CI) 0.95-1.01) on hypertension treatment between losartan and nonlosartan ARB cohort. Post hoc analysis showed that patients initially prescribed eprosartan, irbesartan (both, aHR 1.33), and telmisartan (aHR 1.11) were more likely to discontinue the initial drug, whereas valsartan initiators (aHR 0.96) were less likely compared with losartan initiators.
URI
https://www.tandfonline.com/doi/abs/10.3109/10641963.2015.1116548http://hdl.handle.net/20.500.11754/53830
ISSN
1064-1963; 1525-6006
DOI
10.3109/10641963.2015.1116548
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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