Factors Affecting F-18-FDG Uptake by Metastatic Lymph Nodes in Gastric Cancer
- Title
- Factors Affecting F-18-FDG Uptake by Metastatic Lymph Nodes in Gastric Cancer
- Author
- 김영환
- Keywords
- gastric cancer; F-18-FDG PET; GLUT-1; Ki-67; microvessel density
- Issue Date
- 2013-09
- Publisher
- Lippincott Williams & Wilkins
- Citation
- Journal of computer Assisted Tomography, 2013, 37(5), P.815-819
- Abstract
- Objective: We assessed factors affecting fluorine F 18 fluorodeoxyglucose (F-18-FDG) uptake of metastatic lymph nodes (LNs) in advanced gastric cancer (AGC) due to low F-18-FDG uptake of metastatic LNs in gastric cancer. Methods: Retrospective analyses were performed on 31 patients with AGCs who underwent preoperative F-18-FDG positron emission tomography (PET) and subsequent gastrectomy. Metastatic LNs were compared with primary tumors (on a one-to-one basis) with respect to maximum standardized uptake values, glucose transporter type 1 (GLUT-1) expression, proliferation indices (using Ki-67), microvessel density, and lymphatic vessel density. Results: Maximum standardized uptake values of metastatic LNs were significantly correlated with % GLUT-1 expression (rho = 0.80, P < 0.0001) and Ki-67 labeling index (rho = 0.57, P = 0.001) in LNs. These uptake values were also significantly correlated with SUVs (rho = 0.54; P = 0.002), % GLUT-1 expression (rho = 0.71, P < 0.0001), and Ki-67 labeling index (rho = 0.43, P = 0.019) in primary tumors. In multiple regression analysis, only % GLUT-1 expression in primary tumors and metastatic LNs were significant factors in predicting maximum standardized uptake value of metastatic LNs. Conclusions: In AGCs, GLUT-1 expression and Ki-67 labeling index are important factors in predicting F-18-FDG uptake by metastatic LNs.
- URI
- https://journals.lww.com/jcat/pages/articleviewer.aspx?year=2013&issue=09000&article=00028&type=abstract
- ISSN
- 0363-8715; 1532-3145
- DOI
- 10.1097/RCT.0b013e3182972989
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > ETC
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