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Technology Advancement for Integrative Stem Cell Analyses

Title
Technology Advancement for Integrative Stem Cell Analyses
Author
최종훈
Keywords
HIGH-THROUGHPUT ANALYSIS; ON-A-CHIP; NATURAL-KILLER-CELLS; SINGLE-CELLS; IN-VIVO; INDUCED PLURIPOTENT; SELF-RENEWAL; MICROFLUIDIC DEVICE; EXTRACELLULAR-MATRIX; MICROWELL ARRAYS
Issue Date
2014-07
Publisher
Mary Ann Liebert
Citation
Tissue Engineering. Part B. Reviews, 2014, 20(6), P.669-682
Abstract
Scientists have endeavored to use stem cells for a variety of applications ranging from basic science research to translational medicine. Population-based characterization of such stem cells, while providing an important foundation to further development, often disregard the heterogeneity inherent among individual constituents within a given population. The population-based analysis and characterization of stem cells and the problems associated with such a blanket approach only underscore the need for the development of new analytical technology. In this article, we review current stem cell analytical technologies, along with the advantages and disadvantages of each, followed by applications of these technologies in the field of stem cells. Furthermore, while recent advances in micro/nano technology have led to a growth in the stem cell analytical field, underlying architectural concepts allow only for a vertical analytical approach, in which different desirable parameters are obtained from multiple individual experiments and there are many technical challenges that limit vertically integrated analytical tools. Therefore, we propose-by introducing a concept of vertical and horizontal approach-that there is the need of adequate methods to the integration of information, such that multiple descriptive parameters from a stem cell can be obtained from a single experiment.
URI
https://www.liebertpub.com/doi/abs/10.1089/ten.teb.2014.0141http://hdl.handle.net/20.500.11754/53603
ISSN
1937-3368
DOI
10.1089/ten.teb.2014.0141
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > ETC
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