Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 채필석 | - |
dc.date.accessioned | 2018-03-28T05:47:44Z | - |
dc.date.available | 2018-03-28T05:47:44Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.citation | Colloids and surfaces Biointerfaces, 2014, 123, P.339-344 | en_US |
dc.identifier.issn | 0927-7765 | - |
dc.identifier.issn | 1873-4367 | - |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0927776514005104 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/53292 | - |
dc.description.abstract | This study introduces a drop-based microfluidic approach to physically immobilize liposomes in microgel (liposomes-in-microgel) particles. For this, we generate a uniform liposomes-in-water-in-oil emulsion in a capillary-based microfluidic device. Basically, we have investigated how the flow rate and flow composition affect generation of emulsion precursor drops in micro-channels. Then, the precursor emulsion drops are solidified by photo-polymerization. From characterization of hydrogel mesh sizes, we have figured out that the mesh size of the liposomes-in-microgel particles is bigger than that of bare microgel particles, since liposomes take space in the hydrogel phase. In our further study on drug releasing, we have observed that immobilization of liposomes in the microgel particles can not only remarkably retard drug releasing, but also enables a sustained release, which stems from the enhanced matrix viscosity of the surrounding hydrogel phase. (C) 2014 Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (No. 2008-0061891) and also by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (Grant No.: A103017). This research was also supported by the Korea Institute of Geoscience and Mineral Resources (KIGAM) funded by the Ministry of Knowledge Economy (MEK) of Korea and supported by the R&BD (Research & Business Development) program funded by the Ministry of Trade, Industry and Energy. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier Science B.V., Amsterdam. | en_US |
dc.subject | Liposome | en_US |
dc.subject | Microgel | en_US |
dc.subject | Microfluidics | en_US |
dc.subject | Hydrogel mesh size | en_US |
dc.subject | Drug releasing | en_US |
dc.title | Fabrication of monodisperse liposomes-in-microgel hybrid microparticles in capillary-based microfluidic devices | en_US |
dc.type | Article | en_US |
dc.relation.volume | 123 | - |
dc.identifier.doi | 10.1016/j.colsurfb.2014.09.039 | - |
dc.relation.page | 339-344 | - |
dc.relation.journal | COLLOIDS AND SURFACES B-BIOINTERFACES | - |
dc.contributor.googleauthor | Jeong, Eun-Seon | - |
dc.contributor.googleauthor | Son, Han-Am | - |
dc.contributor.googleauthor | Kim, Min-Kyung | - |
dc.contributor.googleauthor | Park, Kyoung-Ho | - |
dc.contributor.googleauthor | Kay, Se-chan | - |
dc.contributor.googleauthor | Chae, Pil-Seok | - |
dc.contributor.googleauthor | Kim, Jin-Woong | - |
dc.relation.code | 2014027563 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | pchae | - |
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