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Fabrication of monodisperse liposomes-in-microgel hybrid microparticles in capillary-based microfluidic devices

Title
Fabrication of monodisperse liposomes-in-microgel hybrid microparticles in capillary-based microfluidic devices
Author
채필석
Keywords
Liposome; Microgel; Microfluidics; Hydrogel mesh size; Drug releasing
Issue Date
2014-11
Publisher
Elsevier Science B.V., Amsterdam.
Citation
Colloids and surfaces Biointerfaces, 2014, 123, P.339-344
Abstract
This study introduces a drop-based microfluidic approach to physically immobilize liposomes in microgel (liposomes-in-microgel) particles. For this, we generate a uniform liposomes-in-water-in-oil emulsion in a capillary-based microfluidic device. Basically, we have investigated how the flow rate and flow composition affect generation of emulsion precursor drops in micro-channels. Then, the precursor emulsion drops are solidified by photo-polymerization. From characterization of hydrogel mesh sizes, we have figured out that the mesh size of the liposomes-in-microgel particles is bigger than that of bare microgel particles, since liposomes take space in the hydrogel phase. In our further study on drug releasing, we have observed that immobilization of liposomes in the microgel particles can not only remarkably retard drug releasing, but also enables a sustained release, which stems from the enhanced matrix viscosity of the surrounding hydrogel phase. (C) 2014 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0927776514005104http://hdl.handle.net/20.500.11754/53292
ISSN
0927-7765; 1873-4367
DOI
10.1016/j.colsurfb.2014.09.039
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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