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HDL-C levels modify the association between C-reactive protein and coronary artery calcium score

Title
HDL-C levels modify the association between C-reactive protein and coronary artery calcium score
Author
임영효
Keywords
HDL-C; CRP; Coronary artery calcium (CAC) score; Atherosclerosis; Cardio-metabolic risk factors; Cardiovascular disease (CVD)
Issue Date
2014-11
Publisher
Elsevier Science B.V. Amsterdam
Citation
Nutrition, Metabolism and Cardiovascular Diseases, 2014, 24(11), P.1240-1245
Abstract
Backgrounds and aims: C-reactive protein (CRP) levels predict incident and recurrent cardiovascular disease (CVD) events; however, associations between CRP and pre-clinical atherosclerosis is less certain. Since high concentrations of high-density lipoprotein cholesterol (HDL-C) are inversely associated with CVD risk, we investigated whether HDL-C modified the association between CRP concentration and measures of preclinical atherosclerosis. Methods and results: Data were analyzed from a Korean occupational cohort of 12,030 male subjects who underwent a cardiac computed tomography (CT) estimation of coronary artery calcification (CAC) score and an assessment of CVD risk factors. Logistic regression was used to describe associations between CRP and measures of pre-clinical atherosclerosis, such as CAC scores >0. As many as 1351 (11.2%) participants had a CAC score> 0. CRP was stratified into 3 groups based on clinical category: <1 mg/L, 1 to <2 mg/L, and >= 2 mg/dL. In the bottom CRP group, 907/8697 (10.4%) of subjects had a CAC score > 0, compared with 242/1943 (12.5%) in the middle group and 202/1396 (14.5%) in the top CRP group (p < 0.0001). After adjustment for multiple CVD risk factors, there was a positive association between CRP and CAC score> 0 (OR between top and bottom CRP groups, 1.41 [1.04, 1.90], p = 0.027) in the lowest HDL-C quartile but not in the highest HDL-C (OR between top and bottom CRP group, 0.80 [0.46, 1.39], p = 0.425). Conclusion: The association between CRP concentration and CAC score differed according to HDL-C levels. (C) 2014 Elsevier B.V. All rights reserved.
URI
http://www.nmcd-journal.com/article/S0939-4753(14)00200-2/fulltexthttp://hdl.handle.net/20.500.11754/53281
ISSN
0939-4753; 1590-3729
DOI
10.1016/j.numecd.2014.06.003
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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