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dc.contributor.author민경환-
dc.date.accessioned2018-03-28T00:24:29Z-
dc.date.available2018-03-28T00:24:29Z-
dc.date.issued2016-04-
dc.identifier.citationHUMAN PATHOLOGY, v.50, page.90-100en_US
dc.identifier.issn0046-8177-
dc.identifier.issn1532-8392-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0046817715004797?via%3Dihub-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/53162-
dc.description.abstractAmpullary adenocarcinomas (A-ACs) are rare malignancies with considerable importance because of their high curable resection rate and improved survival rate among periampullary cancers. The RAS-RAF-MAPK pathway is involved in the development of A-ACs and is a potential therapeutic target. However, molecular profiles of A-ACs and their prognostic impact are poorly understood. Peptide nucleic acid mediated polymerase chain reaction clamping and Mutyper were used to detect KRAS, BRAF, and PIK3CA mutations in 62 paraffinized samples of A-ACs. Of 62 A-ACs, 30.6% had KRAS mutations, but no BRAF mutations and low frequency (1.6%) of PIK3CA mutation were detected. KRAS mutation was correlated with poor tumor differentiation and was a predictor of shorter recurrence-free survival period in overall A-ACs, whereas the prognosis according to the histologic subtypes was not affected by KRAS mutation. Lymph node metastasis was an independent prognostic factor of poor overall survival. Intestinal- and pancreatobiliary-type A-ACs had similar prognosis. Intestinal- and pancreatobiliary-type A-ACs had different prognostic factors; tumor differentiation and lymph node metastasis strongly predicted overall survival and recurrence-free survival in pancreatobiliary-type tumors, respectively, whereas no independent prognostic factors were demonstrated for intestinal-type tumors. Low incidence of KRAS mutations and their strong prognostic value in A-ACs may suggest the potential of survival benefit depending on the epidermal growth factor receptor targeted therapy. Much lower frequencies of BRAF and PIK3CA mutations may suggest that they do not play a major role in the tumorigenesis of A-ACs. Different therapeutic protocols should be considered for treating pancreatobiliary- and intestinal-type A-ACs. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis research was supported by Hallym University Research Fund (HURF-2014-08).en_US
dc.language.isoenen_US
dc.publisherW B SAUNDERS CO-ELSEVIER INCen_US
dc.subjectAmpulla of Vateren_US
dc.subjectAdenocarcinomaen_US
dc.subjectKRASen_US
dc.subjectBRAFen_US
dc.subjectPIK3CAen_US
dc.subjectMutationen_US
dc.subjectPrognosisen_US
dc.titleLow incidence of KRAS, BRAF, and PIK3CA mutations in adenocarcinomas of the ampulla of Vater and their prognostic valueen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.humpath.2015.11.009-
dc.relation.journalHUMAN PATHOLOGY-
dc.contributor.googleauthorKwon, Mi Jung-
dc.contributor.googleauthorKim, Jeong Won-
dc.contributor.googleauthorJung, Jae Pil-
dc.contributor.googleauthorCho, Ji Woong-
dc.contributor.googleauthorNam, Eun Sook-
dc.contributor.googleauthorCho, Seong Jin-
dc.contributor.googleauthorKim, Joo Seop-
dc.contributor.googleauthorPark, Hye-Rim-
dc.contributor.googleauthorMin, Soo Kee-
dc.contributor.googleauthorMin, Kyueng-Whan-
dc.relation.code2016003743-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkyueng-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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