Harmful Relationship between Alcohol Consumption and Brachial Ankle Pulse Wave Velocity : No Favorable Zone for Vascular Damages
- Harmful Relationship between Alcohol Consumption and Brachial Ankle Pulse Wave Velocity : No Favorable Zone for Vascular Damages
- Alcohol; Carotid intima-media thickness; Mediator; Pulse wave velocity; Subclinical atherosclerosis
- Issue Date
- Federation AMER SOC EXP BIOL
- FASE Journal, 2014, 27, P.1, 767-776
- Background and aims
Arterial stiffness and increased intima-media wall thickness are two of the main predictors of cardiovascular disease (CVD). We evaluated whether brachial-ankle pulse wave velocity (baPWV) and common carotid artery intima-media wall thickness (CCA-IMT) are correlated with alcohol consumption in a cross-sectional study among Korean men and women aged 40 years and over.
Methods and results
All 5539 subjects (2121 men and 3418 women) were participants in the Multi-Rural Communities cohort (MRcohort) study, a part of the Korean Genome Epidemiology Study (KoGES). The baPWV was positively correlated with alcohol consumption in men (p for trend <0.0001). Age (middle-aged versus elderly) modified the effect of alcohol consumption on PWV. On the other hand CCA-IMT decreased with alcohol consumption in men. There was no favorable zone of alcohol consumption in terms of baPWV and CCA-IMT. Adjustment for lipid profiles substantially attenuated the relationship between alcohol consumption and CCA-IMT. There was no clear relation between alcohol consumption and baPWV/CCA-IMT in women.
Along with a linear harmful relationship between alcohol consumption and arterial stiffness in men there may also be a beneficial relationship between alcohol consumption and carotid intima-wall thickness. The effect of alcohol on arterial stiffness may be slightly stronger in elderly men, and the effect of alcohol on CCA-IMT may be mediated by lipid factors.
- 1590-3729; 0939-4753
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- COLLEGE OF MEDICINE[S](의과대학) > ETC
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