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Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP.

Title
Similar outcomes in Asian and Western patients with diffuse large B-cell lymphoma treated with R-CHOP.
Author
송무곤
Keywords
DLBCL; Race; Rituximab; Chemoimmunotherapy; R-CHOP
Issue Date
2013-04
Publisher
Elsevier Science LTD
Citation
Leukemia Research, 2013, 37(4), P.386-391
Abstract
Background: Little is known on racial differences in patients with diffuse large B-cell lymphoma (DLBCL). The aim of this retrospective study is to compare characteristics, prognostic factors and outcomes of Asian and Western patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone (R-CHOP). Methods: Patient-level data was collected from 8 centers. All patients were diagnosed with DLBCL and treated with R-CHOP. Patients were divided into Asian and Western, according to the country of report. Comparisons and univariate/multivariate survival analyses were performed. Results: 712 patients, 455 Asian and 257 Western patients were included. Westerners were more likely to present with elevated LDH (64% vs. 48%, p < 0.01) and advanced stage (58% vs. 49%, p < 0.01). After a median follow-up of 36 months, there was no difference in progression-free (PFS; p = 0.33) or overall survival (OS; p = 0.69). There were no PFS or OS differences between races when evaluating separately each age-adjusted International Prognostic Index category. In the multivariate analyses, performance status and stage were associated with PFS and OS in both races. Conclusions: There are no differences in prognostic factors, PFS and OS between Asian and Western patients with DLBCL treated with R-CHOP. (c) 2013 Elsevier Ltd. All rights reserved.
URI
http://www.lrjournal.com/article/S0145-2126(13)00006-4/fulltexthttp://hdl.handle.net/20.500.11754/52879
ISSN
0145-2126
DOI
10.1016/j.leukres.2013.01.002
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > ETC
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