Comparison of Morphine and Remifentanil on the Duration of Weaning from Mechanical Ventilation

Abstract

Background: A randomized, multicenter, open-label, parallel group study was performed to compare the effects of remifentanil andmorphine as analgesic drugs on the duration of weaning time from mechanical ventilation (MV). Methods: A total of 96 patients with MV in 6 medical and surgical intensive care units were randomly assigned to either, remifentanil(0.1-0.2 mcg/kg/min, n = 49) or morphine (0.8-35 mg/hr, n = 47) from the weaning start. The weaning time was defined as the total ventilationtime minus the sum of controlled mode duration. Results: Compared with the morphine group, the remifentanil-based analgesic group showed a tendency of shorter weaning time (mean143.9 hr, 89.7 hr, respectively: p = 0.069). Secondary outcomes such as total ventilation time, successful weaning rate at the 7th of MVday was similar in both groups. There was also no difference in the mortality rate at the 7th and 28th hospital day. Kaplan-Meyer curvefor weaning was not different between the two groups. Conclusions: Remifentanil usage during the weaning phase tended to decrease weaning time compared with morphine usage.