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Comparison of Morphine and Remifentanil on the Duration of Weaning from Mechanical Ventilation

Title
Comparison of Morphine and Remifentanil on the Duration of Weaning from Mechanical Ventilation
Author
정미애
Keywords
mechanical ventilation; morphine; remifentanil; ventilator weaning
Issue Date
2014-12
Publisher
대한중환자의학회
Citation
대한중환자의학회지 / The Korean Society of Critical Care Medicine, 2014, 29(4), p.281-287(7쪽)
Abstract
Background: A randomized, multicenter, open-label, parallel group study was performed to compare the effects of remifentanil andmorphine as analgesic drugs on the duration of weaning time from mechanical ventilation (MV). Methods: A total of 96 patients with MV in 6 medical and surgical intensive care units were randomly assigned to either, remifentanil(0.1-0.2 mcg/kg/min, n = 49) or morphine (0.8-35 mg/hr, n = 47) from the weaning start. The weaning time was defined as the total ventilationtime minus the sum of controlled mode duration. Results: Compared with the morphine group, the remifentanil-based analgesic group showed a tendency of shorter weaning time (mean143.9 hr, 89.7 hr, respectively: p = 0.069). Secondary outcomes such as total ventilation time, successful weaning rate at the 7th of MVday was similar in both groups. There was also no difference in the mortality rate at the 7th and 28th hospital day. Kaplan-Meyer curvefor weaning was not different between the two groups. Conclusions: Remifentanil usage during the weaning phase tended to decrease weaning time compared with morphine usage.
URI
https://www.e-sciencecentral.org/articles/SC000023259#http://hdl.handle.net/20.500.11754/52640
ISSN
1229-4802
DOI
10.4266/kjccm.2014.29.4.281
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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