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dc.contributor.author민경환-
dc.date.accessioned2018-03-26T08:14:01Z-
dc.date.available2018-03-26T08:14:01Z-
dc.date.issued2014-12-
dc.identifier.citationAPMIS, 2014, 122(12), p.1196-1206en_US
dc.identifier.issn0903-4641-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/abs/10.1111/apm.12285-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/52625-
dc.description.abstractMatrix metalloproteinases (MMPs) are matrix-degrading enzymes that play a pivotal role in aggressive behaviours, such as rapid tumour growth, invasion, and metastasis, of several types of solid tumours. In particular, stromal MMP-2 plays important roles in the progression of malignant tumours, but most clinical studies have focused on tumoural MMP-2 and -9 expression, and not stromal MMP-2 expression. One hundred and seventy-seven cases diagnosed as invasive ductal carcinoma of the breast between 2000 and 2005 were included in this study. Expressions of tumoural MMP-2 and -9 and stromal MMP-2 were analysed by immunostaining on a tissue microarray. Subsequently, the associations between those results and various clinicopathological parameters were evaluated. Stromal MMP-2 expression correlated significantly with clinicopathological parameters such as advanced T category, larger tumour size, high histological grade, tumour necrosis, ER- and PR-negative, and HER-2-positive (all p<0.05). In univariate and multivariate analyses, overall survival was linked with stromal MMP-2 expression as well as dual expression of stromal MMP-2 and tumoural MMP-2 and -9 (all p<0.05). Stromal MMP-2 expression may play a crucial role in predicting aggressive clinical behaviour in breast cancer patients.en_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectMMP2en_US
dc.subjectMMP9en_US
dc.subjectstromal cellen_US
dc.subjectinvasive ductal carcinomaen_US
dc.subjectbreasten_US
dc.titleExpression patterns of stromal MMP-2 and tumoural MMP-2 and -9 are significant prognostic factors in invasive ductal carcinoma of the breasten_US
dc.typeArticleen_US
dc.identifier.doi10.1111/apm.12285-
dc.relation.journalAPMIS-
dc.contributor.googleauthorMin, Kyueng-Whan-
dc.contributor.googleauthorKim, Dong-Hoon-
dc.contributor.googleauthorDo, Sung-Im-
dc.contributor.googleauthorKim, Kyungeun-
dc.contributor.googleauthorLee, Hyun Joo-
dc.contributor.googleauthorChae, Seoung Wan-
dc.contributor.googleauthorSohn, Jin Hee-
dc.contributor.googleauthorPyo, Jung-Soo-
dc.contributor.googleauthorOh, Young-Ha-
dc.contributor.googleauthorKim, Wan-Seop-
dc.relation.code2014025245-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidkyueng-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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