Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 민경환 | - |
dc.date.accessioned | 2018-03-26T08:14:01Z | - |
dc.date.available | 2018-03-26T08:14:01Z | - |
dc.date.issued | 2014-12 | - |
dc.identifier.citation | APMIS, 2014, 122(12), p.1196-1206 | en_US |
dc.identifier.issn | 0903-4641 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/abs/10.1111/apm.12285 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/52625 | - |
dc.description.abstract | Matrix metalloproteinases (MMPs) are matrix-degrading enzymes that play a pivotal role in aggressive behaviours, such as rapid tumour growth, invasion, and metastasis, of several types of solid tumours. In particular, stromal MMP-2 plays important roles in the progression of malignant tumours, but most clinical studies have focused on tumoural MMP-2 and -9 expression, and not stromal MMP-2 expression. One hundred and seventy-seven cases diagnosed as invasive ductal carcinoma of the breast between 2000 and 2005 were included in this study. Expressions of tumoural MMP-2 and -9 and stromal MMP-2 were analysed by immunostaining on a tissue microarray. Subsequently, the associations between those results and various clinicopathological parameters were evaluated. Stromal MMP-2 expression correlated significantly with clinicopathological parameters such as advanced T category, larger tumour size, high histological grade, tumour necrosis, ER- and PR-negative, and HER-2-positive (all p<0.05). In univariate and multivariate analyses, overall survival was linked with stromal MMP-2 expression as well as dual expression of stromal MMP-2 and tumoural MMP-2 and -9 (all p<0.05). Stromal MMP-2 expression may play a crucial role in predicting aggressive clinical behaviour in breast cancer patients. | en_US |
dc.language.iso | en | en_US |
dc.publisher | WILEY-BLACKWELL | en_US |
dc.subject | MMP2 | en_US |
dc.subject | MMP9 | en_US |
dc.subject | stromal cell | en_US |
dc.subject | invasive ductal carcinoma | en_US |
dc.subject | breast | en_US |
dc.title | Expression patterns of stromal MMP-2 and tumoural MMP-2 and -9 are significant prognostic factors in invasive ductal carcinoma of the breast | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1111/apm.12285 | - |
dc.relation.journal | APMIS | - |
dc.contributor.googleauthor | Min, Kyueng-Whan | - |
dc.contributor.googleauthor | Kim, Dong-Hoon | - |
dc.contributor.googleauthor | Do, Sung-Im | - |
dc.contributor.googleauthor | Kim, Kyungeun | - |
dc.contributor.googleauthor | Lee, Hyun Joo | - |
dc.contributor.googleauthor | Chae, Seoung Wan | - |
dc.contributor.googleauthor | Sohn, Jin Hee | - |
dc.contributor.googleauthor | Pyo, Jung-Soo | - |
dc.contributor.googleauthor | Oh, Young-Ha | - |
dc.contributor.googleauthor | Kim, Wan-Seop | - |
dc.relation.code | 2014025245 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | kyueng | - |
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