Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D-3 in human monocytes/macrophages

Title
Regulation of TREM-1 expression by 1,25-dihydroxyvitamin D-3 in human monocytes/macrophages
Author
김태환
Keywords
TREM-1; 1,25-Dihydroxyviamin D-3; Monocytes; Macrophages
Issue Date
2013-08
Publisher
Elsevier Science B.V., Amsterdam.
Citation
Immunology Letters, 2013, 154(1-2), P.80-85
Abstract
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a recently identified cell surface receptor that is expressed mainly on monocytes and neutrophils, and acts as an amplifier of immune responses. In this study, 1,25(OH)(2)D-3 strongly upregulated the expression of TEEM-1 in human monocytes and macrophages. 1,25(OH)(2)D-3 stimulated TREM-1 mRNA expression by augmenting transcription, and not by inhibiting mRNA degradation. The upregulated expression of TREM-1 by 1,25(OH)(2)D-3 was dependent on the NF-kappa B signaling pathway and required new protein synthesis in differentiated U937 macrophages. Our results show that 1,25(OH)(2)D-3 can affect the innate and inflammatory responses by upregulating TEEM-1 expression, and suggest that 1,25(OH)(2)D-3 may function as an enhancer of the innate immune response by upregulating TREM-1 expression, in addition to inducing the antimicrobial peptide cathelicidin. (C) 2013 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/abs/pii/S0165247813001235http://hdl.handle.net/20.500.11754/52461
ISSN
0165-2478; 1879-0542
DOI
10.1016/j.imlet.2013.08.012
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > ETC
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