Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population
- Title
- Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population
- Author
- 고인송
- Keywords
- Interaction; Genome-wide association study; Menarche; Menopause; Single nucleotide polymorphism
- Issue Date
- 2014-05
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
- Citation
- MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY, 21(5), p.522-529
- Abstract
- Objective The aim of this study was to identify polymorphisms and gene-gene interactions that are significantly associated with age at menarche and age at menopause in a Korean population. Methods A total of 3,452 and 1,827 women participated in studies of age at menarche and age at natural menopause, respectively. Linear regression analyses adjusted for residence area were used to perform genome-wide association studies (GWAS), candidate gene association studies, and interactions between the candidate genes for age at menarche and age at natural menopause. Results In GWAS, four single nucleotide polymorphisms (SNPs; rs7528241, rs1324329, rs11597068, and rs6495785) were strongly associated with age at natural menopause (lowest P = 9.66 x 10(-8)). However, GWAS of age at menarche did not reveal any strong associations. In candidate gene association studies, SNPs with P < 0.01 were selected to test their synergistic interactions. For age at natural menopause, there was a significant interaction between intronic SNPs on ADAM metallopeptidase with thrombospondin type I motif 9 (ADAMTS9) and SMAD family member 3 (SMAD3) genes (P = 9.52 x 10(-5)). For age at menarche, there were three significant interactions between three intronic SNPs on follicle-stimulating hormone receptor (FSHR) gene and one SNP located at the 3 ' flanking region of insulin-like growth factor 2 receptor (IGF2R) gene (lowest P = 1.95 x 10(-5)). Conclusions Novel SNPs and synergistic interactions between candidate genes are significantly associated with age at menarche and age at natural menopause in a Korean population.
- URI
- https://journals.lww.com/menopausejournal/pages/articleviewer.aspx?year=2014&issue=05000&article=00014&type=abstracthttp://hdl.handle.net/20.500.11754/52305
- ISSN
- 1072-3714; 1530-0374
- DOI
- 10.1097/GME.0b013e3182a433f7
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > ETC
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML