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incidence of posttransplant malignancy after renal transplantation:single center analysis

Title
incidence of posttransplant malignancy after renal transplantation:single center analysis
Author
권오정
Keywords
Malignancy; Kidney transplantation; Incidence; Multiple primary cancer
Issue Date
2014-12
Publisher
The Korean Society for Transplantation
Citation
대한이식학회지, 권: 28. 호: 4, 페이지: 204-210
Abstract
BackgroundImmunosuppression after kidney transplantation is associated with increased risk of malignancy, which has become the second most common cause of death among kidney transplant recipients. In this review, we report the incidence of malignancies after kidney transplantation in a single center and evaluate the incidence, characteristics, relationship to immunosuppressive drugs and discuss what clinicians must consider during a follow-up of patients after kidney transplantation.MethodsBetween May 1978 and September 2013, a total of 748 kidney transplant patients who were able to undergo a follow-up process through electronic medical records were enrolled in this retrospective cohort study to determine the potential incidence and types of malignancy that may occur after kidney transplantation and the associated impact on patients and graft survival.ResultsAmong 748 patients, 63 cases of malignancy appeared in 54 patients (7.2%). Gastrointestinal cancer (12 cases, 19%) and post-transplant lymphoproliferative disorder (12 cases, 19%) were the two most common types of malignancy. The second most common type of malignancy was urinary tract malignancy in 10 patients. Two different types of malignancy were diagnosed in nine patients during our follow-up. The overall graft survival in malignancy patients was better, which may mean that malignancy did not affect the overall graft loss.ConclusionsClinicians should be aware of the incidence of malignancy in transplant patients and perform routine examinations for early detection of malignancy.
URI
https://synapse.koreamed.org/DOIx.php?id=10.4285/jkstn.2014.28.4.204http://hdl.handle.net/20.500.11754/51977
ISSN
1598-1711
DOI
10.4285/jkstn.2014.28.4.204
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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