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Oxygen distribution in proteins defines functional significance of the genome and proteome of the malaria parasite Plasmodium falciparum 3D7

Title
Oxygen distribution in proteins defines functional significance of the genome and proteome of the malaria parasite Plasmodium falciparum 3D7
Author
Klaus Heese
Keywords
malaria; oxygen; nitrogen; sulfur
Issue Date
2014-02
Publisher
WILEY-BLACKWELL
Citation
FEMS MICROBIOLOGY LETTERS; FEB 2014, 351, 1, p59-p63
Abstract
Although GlaxoSmithKline is on the way to launch the new vaccine candidate RTS, S', the search for suitable antimalarial drugs still remains an exceeding challenge because Plasmodium falciparum-mediated malaria is one of the most lethal diseases in the world. Novel innovative ideas are required to identify new potential molecular targets to be able to fight this lethal parasite efficiently. We used an unconventional bioinformatics approach to analyze the entire genome and proteome of the Pf3D7 strain. Because the oxygen (O-) content is a decisive parameter that determines the function of a protein, we analyzed the entire Pf3D7 proteome based on O-containing amino acid expression. Our data disclose a total of four proteins encoded by chromosome (Chr)-4 and Chr-9 that have an outstanding O-controlled character. The identification of the biological significance of these proteins could eventually lead to new vital drug targets.
URI
https://academic.oup.com/femsle/article/351/1/59/501726http://hdl.handle.net/20.500.11754/51858
ISSN
0378-1097
DOI
10.1111/1574-6968.12355
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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