Skin regeneration with fibroblast growth factor 2 released from heparin-conjugated fibrin
- Title
- Skin regeneration with fibroblast growth factor 2 released from heparin-conjugated fibrin
- Author
- 임태연
- Keywords
- Fibroblast growth factor 2; Heparin-conjugated fibrin; Skin regeneration; Vascularization
- Issue Date
- 2011-04
- Publisher
- Springer
- Citation
- Biotechnology Letters, 2011, 33(4), P.845-851
- Abstract
- Fibroblast growth factor 2 (FGF2) stimulates skin wound healing but does long-term delivery of FGF2 enhance skin regeneration compared to short-term delivery? Heparin-conjugated fibrin (HCF) was used as a vehicle for long-term delivery of FGF2. Fibrin, HCF, FGF2-loaded fibrin, and FGF2-loaded HCF were implanted into full-thickness skin defects of mice. The neoepidermis thickness was significantly larger in the FGF2-loaded HCF group than in the other groups, except for the FGF2-loaded fibrin group. Suprabasal cytokeratin differentiation in squamous neoepithelium was greatest in the FGF2-loaded HCF group. The enhanced skin regeneration accompanying the long-term delivery of FGF2 could be mediated, at least partially, by enhanced neovascularization and cell proliferation in the neodermis.
- URI
- https://link.springer.com/article/10.1007%2Fs10529-010-0492-5
- ISSN
- 0141-5492
- DOI
- 10.1007/s10529-010-0492-5
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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