Increasing prevalence of bla(OXA-23)-carrying Acinetobacter baumannii and the emergence of bla(OXA-182)-carrying Acinetobacter nosocomialis in Korea

Title
Increasing prevalence of bla(OXA-23)-carrying Acinetobacter baumannii and the emergence of bla(OXA-182)-carrying Acinetobacter nosocomialis in Korea
Author
이양순
Keywords
bla(OXA-182); bla(OXA-23); Acinetobacter nosocomialis; Acinetobacter baumannii; OXA CARBAPENEMASES; SPP.; GENES; DISSEMINATION; EXPRESSION; PCR
Issue Date
2013-10
Publisher
ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Citation
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2013, 77(2), P.160-163
Abstract
Carbapenem-resistant Acinetobacter spp. have been increasingly reported worldwide with the production of OXA-type carbapenemases as the main mechanism of carbapenem resistance. The prevalent bla(OXA) genes are known to vary significantly depending on time and place of isolation. We investigated the prevalence of bla(OXA) genes by PCR in Acinetobacter spp. isolated in Korea. Among a total of 336 isolates collected from Hospital A from 2002 to 2011, the overall proportion of bla(OXA-23)-like, ISAba1-associated bla(OXA-51)-like, and bla(OXA-182) genes were 44.0%, 49.7%, and 5.1%, respectively. The bla(OXA-58)-like gene was detected in only 1 isolate. A drastic increase in Acinetobacter isolates with bla(OXA-23)-like genes and a decrease in isolates harboring ISAba1-associated bla(OXA-51)-like genes have been observed since the mid-2000s. The bla(OXA-23)-like genes were detected in all carbapenem-nonsusceptible isolates collected in 2011 from 9 hospitals. The OXA-182, which belongs to the fifth group of OXA-type carbapenemase, was detected in Acinetobacter baumannii isolates recovered as early as 2002. It is worrisome results that bla(OXA-182)-carrying Acinerobacter nosocomialis has emerged and caused outbreaks of infection. (C) 2013 Elsevier Inc. All rights reserved.
URI
https://ac.els-cdn.com/S0732889313003416/1-s2.0-S0732889313003416-main.pdf?_tid=dca52c78-d6ca-4546-8302-7299d34dfb87&acdnat=1520859393_ea55767f6957dbfdbb80f7e2b495606ahttp://hdl.handle.net/20.500.11754/51694
ISSN
0732-8893; 1879-0070
DOI
10.1016/j.diagmicrobio.2013.06.009
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE