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dc.contributor.author전대원-
dc.date.accessioned2018-03-23T07:44:14Z-
dc.date.available2018-03-23T07:44:14Z-
dc.date.issued2014-11-
dc.identifier.citationWORLD JOURNAL OF GASTROENTEROLOGY, 권: 20, 호: 35, 페이지: 12526-12532en_US
dc.identifier.issn1007-9327-
dc.identifier.issn2219-2840-
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168087/-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/51548-
dc.description.abstractCell death has been extensively evaluated for decades and it is well recognized that pharmacological interventions directed to inhibit cell death can prevent significant cell loss and can thus improve an organ' s physiological function. For long, only apoptosis was considered as a sole form of programmed cell death. Recently necroptosis, a RIP1/RIP3-dependent programmed cell death, has been identified as an apoptotic backup cell death mechanism with necrotic morphology. The evidences of necroptosis and protective effects achieved by blocking necroptosis have been extensively reported in recent past. However, only a few studies reported the evidence of necroptosis and protective effects achieved by inhibiting necroptosis in liver related disease conditions. Although the number of necroptosis initiators is increasing; however, interestingly, it is still unclear that what actually triggers necroptosis in different liver diseases or if there is always a different necroptosis initiator in each specific disease condition followed by specific downstream signaling molecules. Understanding the precise mechanism of necroptosis as well as counteracting other cell death pathways in liver diseases could provide a useful insight towards achieving extensive therapeutic significance. By targeting necroptosis and/or other parallel death pathways, a significant cell loss and thus a decrement in an organ's physiological function can be prevented. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.en_US
dc.description.sponsorshipSupported by A grant of the Korea Healthcare technology R and D Project, Ministry of Health and Welfare, South Korea, NO. A121185en_US
dc.language.isoenen_US
dc.publisherBAISHIDENG PUBLISHING GROUP INC, 8226 REGENCY DR, PLEASANTON, CA 94588 USAen_US
dc.subjectNecroptosisen_US
dc.subjectProgrammed necrosisen_US
dc.subjectApoptosisen_US
dc.subjectCell deathen_US
dc.subjectLiver diseaseen_US
dc.titleNecroptosis: An emerging type of cell death in liver diseasesen_US
dc.typeArticleen_US
dc.relation.no35-
dc.relation.volume20-
dc.identifier.doi10.3748/wjg.v20.i35.12526-
dc.relation.page12526-12532-
dc.relation.journalWORLD JOURNAL OF GASTROENTEROLOGY-
dc.contributor.googleauthorJun, Dae-Won-
dc.contributor.googleauthorSaeed, Waqar Khalid-
dc.relation.code2014040901-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidnoshin-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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