Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2018-03-23T05:55:34Z | - |
dc.date.available | 2018-03-23T05:55:34Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.citation | RHEUMATOLOGY INTERNATIONAL , 권: 34 , 호: 4, 페이지: 465-471 | en_US |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.issn | 1437-160X | - |
dc.identifier.uri | http://link.springer.com/article/10.1007/s00296-013-2919-5 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/51333 | - |
dc.description.abstract | The aim of this study was to determine whether the tumor necrosis factor-alpha (TNF-alpha) promoter -308 A/G polymorphism is associated with susceptibility to rheumatoid arthritis (RA) in populations with different ethnicities. MEDLINE and EMBASE databases and manual search were used to identify articles in which TNF-alpha polymorphism was determined in RA patients and controls. A meta-analysis was conducted on the associations between the TNF-alpha -308 A/G polymorphism and RA by using (1) allelic contrast and (2) dominant models. A total of 19 studies involving 2,584 RA patients and 3,254 controls were considered. The meta-analysis showed no association between the TNF-alpha -308 A allele and RA when all the subjects were considered [odds ratio (OR) = 1.129, 95 % CI 0.843-1.513, P = 0.416]. After stratification by ethnicity, the meta-analysis indicated that the A allele was significantly associated with RA in Latin Americans (OR = 1.620, 95 % CI 1.234-2.111, P = 3.6 x 10(-5)), but not in the European, Arab, or Asian populations. The meta-analysis of the AA/AG genotype showed the same pattern of results as with the A allele. No association was noted between the AA/AG genotype and RA when all the subjects were considered (OR = 1.114, 95 % CI 0.812-1.529, P = 0.503), but stratification by ethnicity revealed that the AA/AG genotype was significantly associated with RA in Latin Americans (OR = 1.650, 95 % CI 1.234-2.104, P = 0.001). This meta-analysis showed that the TNF-alpha -308 A/G polymorphism may represent a significant risk factor for RA in Latin Americans but not in the European, Arab, or Asian populations. | en_US |
dc.description.sponsorship | This study is supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER HEIDELBERG, TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY | en_US |
dc.subject | NECROSIS-FACTOR-ALPHA | en_US |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | en_US |
dc.subject | SINGLE NUCLEOTIDE POLYMORPHISMS | en_US |
dc.subject | GENE POLYMORPHISM | en_US |
dc.subject | HLA ALLELES | en_US |
dc.subject | SUSCEPTIBILITY | en_US |
dc.subject | SEVERITY | en_US |
dc.subject | DISEASE | en_US |
dc.subject | REGION | en_US |
dc.subject | POPULATION | en_US |
dc.title | Association between TNF-alpha promoter-308 A/G polymorphism and rheumatoid arthritis: a meta-analysis | en_US |
dc.title.alternative | G polymorphism and rheumatoid arthritis: a meta-analysis | en_US |
dc.type | Article | en_US |
dc.relation.volume | 34 | - |
dc.identifier.doi | 10.1007/s00296-013-2919-5 | - |
dc.relation.page | 465-471 | - |
dc.relation.journal | RHEUMATOLOGY INTERNATIONAL | - |
dc.contributor.googleauthor | Song, Gwan Gyu | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.contributor.googleauthor | Kim, Jae-Hoon | - |
dc.contributor.googleauthor | Lee, Young H | - |
dc.relation.code | 2014038981 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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