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Effects of pargyline on cellular proliferation in human breast cancer cells

Title
Effects of pargyline on cellular proliferation in human breast cancer cells
Author
채영규
Keywords
Apoptosis; Breast cancer cells; Cellular proliferation; Cleaved PARP; Lysine-specific demethylase 1; Pargyline
Issue Date
2012-12
Publisher
Korean Society of Toxicogenomics and Toxicoproteomics
Citation
Molecular & Cellular Toxicology, 2012, 8(4), P.393-399
Abstract
Monoamine oxidase (MAO) inhibitors have been tested for the purpose of treating many types of cancers including breast cancer. Pargyline, an MAO inhibitor, prevents the activity of lysine-specific demethylase 1 (LSD1), which is excessively expressed in breast cancer. The purpose of this study is to investigate the effect of pargyline on cellular proliferation in human breast ductal carcinoma (T47D) cells. After exposing T47D cells to pargyline, we examined cell proliferation, cell cycle, apoptosis, and the expression levels of apoptosis-related proteins and LSD1. The proliferation of cells exposed to pargyline decreased in a dose- and time-dependent manner. The treatment of 2 mM pargyline exhibited an increase of the cell proportion at the G1 phase, while the major decrease of the cell proportion was at the S phase compared to the controls. In addition, pargyline induced an increase in the cleaved PARP expression. However, we did not find a change in the LSD1 expression in the cells exposed to pargyline. Based on our results, it is believed that pargyline has pharmaceutical potential as an anticancer drug for the treatment of human breast cancer.
URI
https://link.springer.com/article/10.1007%2Fs13273-012-0048-yhttp://hdl.handle.net/20.500.11754/51283
ISSN
1738-642X; 2092-8467
DOI
10.1007/s13273-012-0048-y
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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