Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김진웅 | - |
dc.date.accessioned | 2018-03-23T05:24:48Z | - |
dc.date.available | 2018-03-23T05:24:48Z | - |
dc.date.issued | 2014-11 | - |
dc.identifier.citation | ORGANIC & BIOMOLECULAR CHEMISTRY, 권: 12, 호: 42, 페이지: 8480-8487 | en_US |
dc.identifier.issn | 1477-0520 | - |
dc.identifier.issn | 1477-0539 | - |
dc.identifier.uri | http://pubs.rsc.org/en/Content/ArticleLanding/2014/OB/C4OB01375A#!divAbstract | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/51266 | - |
dc.description.abstract | Detergents are widely used for membrane protein research; however, membrane proteins encapsulated in micelles formed by conventional detergents tend to undergo structural degradation, necessitating the development of new agents with enhanced efficacy. Here we prepared several hydrophobic variants of ganglio-tripod amphiphiles (TPAs) derived from previously reported TPAs and evaluated for a multi-subunit, pigment protein superassembly. In this study. TPA-16 was found to be most efficient in protein solubilization while TPA-15 proved most favourable in long-term protein stability. The current study combined with previous TPA studies enabled us to elaborate on a few detergent structure-property relationships that could provide useful guidelines for novel amphiphile design. | en_US |
dc.description.sponsorship | This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (grant number 2008-0061891 and 2013R1A2A2A03067623 to P. S. C. and H. E. B., M. E. and H. H.). We thank Philip Laible (Argonne National Laboratory) for providing membrane preparations from R. capsulatus. | en_US |
dc.language.iso | en | en_US |
dc.publisher | ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND | en_US |
dc.subject | MUSCARINIC ACETYLCHOLINE-RECEPTOR | en_US |
dc.title | New ganglio-tripod amphiphiles (TPAs) for membrane protein solubilization and stabilization: implications for detergent structure-property relationships | en_US |
dc.type | Article | en_US |
dc.relation.volume | 12 | - |
dc.identifier.doi | 10.1039/c4ob01375a | - |
dc.relation.page | 8480-8487 | - |
dc.relation.journal | ORGANIC & BIOMOLECULAR CHEMISTRY | - |
dc.contributor.googleauthor | Chae, Pil Seok | - |
dc.contributor.googleauthor | Bae, Hyoung Eun | - |
dc.contributor.googleauthor | Ehsan, Muhammad | - |
dc.contributor.googleauthor | Hussain, Hazrat | - |
dc.contributor.googleauthor | Kim, Jin Woong | - |
dc.relation.code | 2014037105 | - |
dc.sector.campus | S | - |
dc.sector.daehak | GRADUATE SCHOOL[S] | - |
dc.sector.department | DEPARTMENT OF BIONANOTECHNOLOGY | - |
dc.identifier.pid | kjwoong | - |
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