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Effects of DA-9701, a Novel Prokinetic Agent, on Phosphorylated Extracellular Signal-Regulated Kinase Expression in the Dorsal Root Ganglion and Spinal Cord Induced by Colorectal Distension in Rats

Title
Effects of DA-9701, a Novel Prokinetic Agent, on Phosphorylated Extracellular Signal-Regulated Kinase Expression in the Dorsal Root Ganglion and Spinal Cord Induced by Colorectal Distension in Rats
Author
이항락
Keywords
DA-9701; Visceral hypersensitivity; Visceral hypersensitivity
Issue Date
2014-03
Publisher
The Editorial Office of Gut and Liver
Citation
GUT AND LIVER, Vol.8 No.2 [2014], pp. 140-147
Abstract
Background/Aims: DA-9701, a standardized extract ofPharbitis Semen and Corydalis Tuber, is a new prokineticagent that exhibits an analgesic effect on the abdomen. Weinvestigated whether DA-9701 affects visceral pain inducedby colorectal distension (CRD) in rats.Methods: A total of21 rats were divided into three groups: group A (no CRD+nodrug), group B (CRD+no drug), and group C (CRD+DA-9701). Expression of pain-related factors, substance P (SP), c-fos,and phosphorylated extracellular signal-regulated kinase (p-ERK) in the dorsal root ganglion (DRG) and spinal cord wasdetermined by immunohistochemical staining and Westernblotting.Results: The proportions of neurons in the DRGand spinal cord expressing SP, c-fos, and p-ERK were higherin group B than in group A. In the group C, the proportion ofneurons in the DRG and spinal cord expressing p-ERK waslower than that in group B. Western blot results for p-ERK inthe spinal cord indicated a higher level of expression in groupB than in group A and a lower level of expression in group Cthan in group B.Conclusions: DA-9701 may decrease visceralpain via the downregulation of p-ERK in the DRG andspinal cord.
URI
http://www.gutnliver.org/journal/view.html?volume=8&number=2&spage=140&year=2014http://hdl.handle.net/20.500.11754/51264
ISSN
1976-2283; 2005-1212
DOI
10.5009/gnl.2014.8.2.14010.5009/gnl.2014.8.2.140
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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