Injectable microsphere/hydrogel hybrid system containing heat shock protein as therapy in a murine myocardial infarction model
- Title
- Injectable microsphere/hydrogel hybrid system containing heat shock protein as therapy in a murine myocardial infarction model
- Other Titles
- hydrogel hybrid system containing heat shock protein as therapy in a murine myocardial infarction model
- Author
- 이상경
- Keywords
- Heat shock protein; microsphere/hydrogel hybrid system; myocardial infarction
- Issue Date
- 2013-11
- Publisher
- Informa Healthcare
- Citation
- Journal of Drug Targeting, 2013, 21(9), P.822-829
- Abstract
- Abstract Heat shock proteins, acting as molecular chaperones, protect heart muscle from ischemic injury and offer a potential approach to therapy. Here we describe preparation of an injectable form of heat shock protein 27, fused with a protein transduction domain (TAT-HSP27) and contained in a hybrid system of poly(D,L-lactic-co-glycolic acid) microsphere and alginate hydrogel. By varying the porous structure of the microspheres, the release of TAT-HSP27 from the hybrid system was sustained for two weeks in vitro. The hybrid system containing TAT-HSP27 was intramyocardially injected into a murine myocardial infarction model, and its therapeutic effect was evaluated in vivo. The sustained delivery of TAT-HSP27 substantially suppressed apoptosis in the infarcted site, and improved the ejection fraction, end-systolic volume and maximum pressure development in the heart. Local and sustained delivery of anti-apoptotic proteins such as HSP27 using a hybrid system may present a promising approach to the treatment of ischemic diseases.
- URI
- http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=21&SID=E6agZCZNmLFKP2xDlNX&page=1&doc=1http://hdl.handle.net/20.500.11754/50986
- ISSN
- 1061-186X; 1029-2330
- DOI
- 10.3109/1061186X.2013.829072
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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