Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이현 | - |
dc.date.accessioned | 2018-03-23T01:28:41Z | - |
dc.date.available | 2018-03-23T01:28:41Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.citation | American Journal of Respiratory Cell and Molecular Biology. Apr 01, 2014, 50, 4, 667-677 | en_US |
dc.identifier.issn | 1044-1549 | - |
dc.identifier.uri | https://www.atsjournals.org/doi/abs/10.1165/rcmb.2013-0397TR | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/50984 | - |
dc.description.abstract | Insulin-like growth factor (IGF)-I has been recognized to play critical roles in the pathogenesis of asthma, whereas IGF-binding protein (IGFBP)-3 blocks crucial physiologic manifestations of asthma. IGF-I enhances subepithelial fibrosis, airway inflammation, airway hyperresponsiveness, and airway smooth muscle hyperplasia by interacting with various inflammatory mediators and complex signaling pathways, such as intercellular adhesion molecule-1, and the hypoxia-inducible factor/vascular endothelial growth factor axis. On the other hand, IGFBP-3 decreases airway inflammation and airway hyperresponsiveness through IGFBP-3 receptor-mediated activation of caspases, which subsequently inhibits NF-κB signaling pathway. It also inhibits the IGF-I/hypoxia-inducible factor/vascular endothelial growth factor axis via IGF-I-dependent and/or IGF-I-independent mechanisms. This Translational Review summarizes the role of IGF-I and IGFBP-3 in the context of allergic airway disease, and discusses the therapeutic potential of various strategies targeting the IGF-I and IGFBP-3 signaling pathways for the management of asthma. | en_US |
dc.description.sponsorship | This work was supported by Korea Healthcare Technology R&D Project, Ministry for Health and Welfare, Republic of Korea grants A121931 (Y.C.L.) and A111992 (S.R.K.), and by the funds of the Biomedical Research Institute, Chonbuk National University Hospital. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Thoracic Society | en_US |
dc.subject | insulin-like growth factor-I | en_US |
dc.subject | insulin-like growth factor?binding protein-3 | en_US |
dc.subject | asthma | en_US |
dc.title | Targeting insulin-like growth factor-I and insulin-like growth factor-binding protein-3 signaling pathways. A novel therapeutic approach for asthma | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1165/rcmb.2013-0397TR | - |
dc.relation.journal | AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | - |
dc.contributor.googleauthor | Lee, Hyun, | - |
dc.contributor.googleauthor | Kim, So Ri | - |
dc.contributor.googleauthor | Oh, Youngman | - |
dc.contributor.googleauthor | Cho, Seong Ho | - |
dc.contributor.googleauthor | Schleimer, Robert P. | - |
dc.contributor.googleauthor | Lee, Yong Chul | - |
dc.relation.code | 2014024759 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | namuhanayeyo | - |
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