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Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain

Title
Characterization of the novel protein P9TLDR (temporal lobe down-regulated) with a brain-site-specific gene expression modality in Alzheimer's disease brain
Author
Klaus Heese
Keywords
Alzheimer's disease; Amyloid; Brain; Mapt; Neurotoxicity; Neurodegeneration; Tau
Issue Date
2012-12
Publisher
Elsevier Science B.V., Amsterdam.
Citation
FEBS letters, 2012, 586(24), P.4357-4361
Abstract
Alzheimer's disease (AD) is an aging-related neurodegenerative disorder characterized by irreversible loss of higher cognitive functions. The disease is characterized by the presence of amyloid plaques and neurofibrillary tangles (NFT). In the current study we isolated from an intra-cerebral brain-site-specific (AD temporal lobe vs. AD occipital lobe) polymerase chain reaction (PCR)-select cDNA suppression subtractive hybridization (PCR-cDNA-SSH) expression analysis the novel gene P9TLDR, potentially a microtubule-associated protein involved in neuronal migration, with an altered expression pattern: down-regulated in the temporal lobe cortex of early stage AD brains. In an in vitro AD-related cell model, amyloid-β peptide (Aβ)-treated neurons, reduced P9TLDR expression correlated with increased tau protein phosphorylation. In conclusion, interference with the P9TLDR signalling pathways might be a therapeutic strategy for the treatment of AD.
URI
https://febs.onlinelibrary.wiley.com/doi/abs/10.1016/j.febslet.2012.10.050http://hdl.handle.net/20.500.11754/50962
ISSN
0014-5793
DOI
10.1016/j.febslet.2012.10.050
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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