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dc.contributor.author신진호-
dc.date.accessioned2018-03-22T07:54:31Z-
dc.date.available2018-03-22T07:54:31Z-
dc.date.issued2013-07-
dc.identifier.citationPlos One, 2013, 8(7), e70246en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=22&SID=D2XtGHm3BhOATRmp4rv&page=1&doc=1-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/50754-
dc.description.abstractBackground: Adiponectin directly protects against cardiac remodeling. Despite this beneficial effect, most epidemiological studies have reported a negative relationship between adiponectin level and left ventricular mass index (LVMI). However, a positive relationship has also been reported in subjects at high risk of left ventricular hypertrophy (LVH). Based on these conflicting results, we hypothesized that the relationship between serum adiponectin level and LVMI varies with the risk of LVH.Methods: A community-based, cross-sectional study was performed on 1414 subjects. LVMI was measured by echocardiography. Log-transformed adiponectin levels (Log-ADPN) were used for the analysis.Results: Serum adiponectin level had a biphasic distribution (an increase after a decrease) with increasing LVMI. Although Log-ADPN did not correlate with LVMI, Log-ADPN was modestly associated with LVMI in the multivariate analysis (beta = 0.079, p = 0.001). The relationship between adiponectin level and LVMI was bidirectional according to the risk of LVH. In normotensive subjects younger than 50 years, Log-ADPN negatively correlated with LVMI (r = -0.204, p = 0.005); however, Log-ADPN positively correlated with LVMI in >= 50-year-old obese subjects with high arterial stiffness (r = 0.189, p = 0.030). The correlation coefficient between Log-ADPN and LVMI gradually changed from negative to positive with increasing risk factors for LVH. The risk of LVH significantly interacted with the relationship between Log-ADPN and LVMI. In the multivariate analysis, Log-ADPN was associated with LVMI in the subjects at risk of LVH; however, Log-ADPN was either not associated or negatively associated with LVMI in subjects at low risk of LVH.Conclusion: Adiponectin level and LVMI are negatively associated in subjects at low risk of LVH and are positively associated in subjects at high risk of LVH. Therefore, the relationship between adiponectin and LVMI varies with the risk of LVH.en_US
dc.description.sponsorshipFunded by Hanyang University, Preventive Medicine. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.language.isoenen_US
dc.publisherPublic Library Scienceen_US
dc.subjectBRAIN NATRIURETIC PEPTIDEen_US
dc.subjectCHRONIC HEART-FAILUREen_US
dc.subjectPLASMA ADIPONECTINen_US
dc.subjectINSULIN-RESISTANCEen_US
dc.subjectMETABOLIC SYNDROMEen_US
dc.subjectHUMAN ADIPOCYTESen_US
dc.subjectASSOCIATIONen_US
dc.subjectOBESITYen_US
dc.subjectHYPERTENSIONen_US
dc.subjectMORTALITYen_US
dc.titleThe Relationship between Adiponectin and Left Ventricular Mass Index Varies with the Risk of Left Ventricular Hypertrophyen_US
dc.typeArticleen_US
dc.relation.no7-
dc.relation.volume8-
dc.identifier.doi10.1371/journal.pone.0070246-
dc.relation.page1-8-
dc.relation.journalPLOS ONE-
dc.contributor.googleauthorLee, Yong-Gu-
dc.contributor.googleauthorKim, Bae-Keun-
dc.contributor.googleauthorLim, Young-Hyo-
dc.contributor.googleauthorKim, Mi-Kyung-
dc.contributor.googleauthorChoi, Bo-Youl-
dc.contributor.googleauthorShin, Jin-Ho-
dc.relation.code2013007124-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidjhs2003-
dc.identifier.researcherID55458954400-
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COLLEGE OF MEDICINE[S](의과대학) > ETC
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