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Proteomic analysis of pancreas in miniature pigs according to developmental stages using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry

Title
Proteomic analysis of pancreas in miniature pigs according to developmental stages using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry
Other Titles
ionization-time of flight mass spectrometry
Author
황승용
Keywords
Organ transplantation is limited by the shortage of human organs. Many studies have sought to overcome this hurdle by using animal organs. Porcine organs, especially from miniature pigs, have been used for organ xenotransplantation rather than nonhuman primates. While the molecular profiling for transplantation is well known in humans and rodents, the situation for pigs is almost completely unknown. The present study examined protein regulation of the developing stages of the pancreatic proteome (4 day-old miniature neonate, 19 day-old miniature piglet, and 14 month-old miniature adult pigs) using two-dimensional gel electrophoresis and matrix assisted laser desorption/ionization-time of flight mass spectrometry. Thirteen different expressed spots were observed and nine were identified. The data presented within this study provides critical direction relating to the development of pancreas of miniature pigs, which will assist future proteome analysis of the pancreas, and advance our understanding of the hurdles facing xenotransplantation.
Issue Date
2014-03
Publisher
한국실험동물학회
Citation
Laboratory animal research,v.30,no.1 2014년, pp.1 - 7
Abstract
Human organpancreasminiature pigproteome2-DE MALDI-TOF
URI
https://synapse.koreamed.org/DOIx.php?id=10.5625/lar.2014.30.1.1http://hdl.handle.net/20.500.11754/50634
ISSN
1738-6055; 2233-7660
DOI
10.5625/lar.2014.30.1.1
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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