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Enhanced-throughput production of polymersomes using a parallelized capillary microfluidic device

Title
Enhanced-throughput production of polymersomes using a parallelized capillary microfluidic device
Author
김진웅
Keywords
Microfluidics; Polymersomes; Emulsions; Microcapsules; Parallelization
Issue Date
2013-03
Publisher
Springer
Citation
Microfluidics and Nanofluidics, 2013, 14(3-4), P.509-514
Abstract
We report a parallelized capillary microfluidic device for enhanced production rate of monodisperse polymersomes. This device consists of four independent capillary microfluidic devices, operated in parallel; each device produces monodisperse water-in-oil-in-water (W/O/W) double-emulsion drops through a single-step emulsification. During generation of the double-emulsion drops, the innermost water drop is formed first and it triggers a breakup of the middle oil phase over wide range of flow rates; this enables robust and stable formation of the double-emulsion drops in all drop makers of the parallelized device. Double-emulsion drops are transformed to polymersomes through a dewetting of the amphiphile-laden middle oil phase on the surface of the innermost water drop, followed by the subsequent separation of the oil drop. Therefore, we can make polymersomes with a production rate enhanced by a factor given by the number of drop makers in the parallelized device.
URI
https://link.springer.com/article/10.1007%2Fs10404-012-1069-5
ISSN
1613-4982; 1613-4990
DOI
10.1007/s10404-012-1069-5
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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